Complex changes of circadian proteins expression in inflammatory bowel disease

Objectives and background Recently, a possible role of circadian system in the pathogenesis various gastrointestinal disorders gained an attention. The association with immune activity reciprocal connection intestinal microbiota indicate links inflammatory bowel diseases (IBD). Methods retrospective study provided semiquantitative immunohistochemical analysis expression 8 core proteins (BMAL1, BMAL2, PER1, PER2, PER3, CLOCK, NPAS2 TIMELESS) epithelial cells mucosa 24 patients Crohn's disease (CD) 26 ulcerative colitis (UC). Samples from without history IBD served as control. BMAL1 protein intramucosal was explored well. Results 5 TIMELESS NAPS2) decreased mucosal epithelium comparison control samples, whereas PER1 more noticeably UC CD patients. There Conclusion Decreased colonic indicated rhythm deregulation contributing factor development IBD. To our knowledge, this is so far most extensive performed on samples evaluating changes (Tab. 1, Fig. 2, Ref. 31).